The most comprehensive study yet undertaken, incorporating the most reliable risk estimates so far achieved, has shown that hormone replacement therapy (HRT), also known as menopausal hormone therapy (MHT), did not increase the risk of dementia in women. The research team was led by Dr Yana Vinogradova of the School of Medicine of the University of Nottingham in the UK, but included experts from two other British universities, namely Oxford and Southampton. The researchers used data from two of Britain’s largest medical databases, the Oxford University-based QResearch and the UK Department of Health’s Clinical Practice Research Datalink. The study used data for 615 917 women, aged 55 and older, gathered from 1998 to 2020. Of these, 118 501 had been diagnosed with dementia while the other 497 416, who had not been diagnosed with dementia, acted as the control group for the study.
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